EPB41L2 — Erythrocyte membrane protein band 4.1 like 2

EPB41L2 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EPB41L2's module in each cell type

Cell type	Module	Shares the module with
Endothelial	EC Cytoskeletal Scaffold Cytoskeletal	ADD3, ANTXR2, CTSD, FXYD6, GYPC, MAP4K2, NRP2, RECK +2 more	View in SCUBA
Enterocytes	Basal adhesion remodeling Migration & adhesion	ETS2, FNDC3B, HERC4, ITGA6, NT5C2, SESTD1, SGMS1, SH3RF1 +2 more	View in SCUBA
Fibroblasts	Homeostatic Stromal Identity ECM production	ADAMTSL1, ADAMTSL3, KAZALD1, LRIG1, NFIB, NUPR1, PDE5A, PLXDC1 +4 more	View in SCUBA
Glial cells	Glial Adhesion Cytoskeletal migration & adhesion	AKAP9, COL21A1, DOCK5, KIAA1217, LTBP3, NCAM1, RALGPS2, SCN7A +1 more	View in SCUBA
Lymphatic endothelial	Actin Cytoskeletal Scaffold Cytoskeletal	CCDC102B, CCND3, DAAM1, DPYSL3, GOLM2, GPATCH2, KLHL4, PPFIBP1 +1 more	View in SCUBA
Macrophages	Macrophage Migration Migration & adhesion	CEMIP2, CPM, EPS8, GBE1, ITGA9, KCNQ1, MAN1A1, MEF2C +12 more	View in SCUBA
Monocytes	Tissue Macrophage Identity Tissue homeostasis	CMKLR1, CREBL2, CSF1R, DST, SCARB2, SLC46A1, SNX5	View in SCUBA
Pericytes	Pericyte Identity Differentiation Developmental	ADAMTS5, ARHGAP15, GUCY1A1, INPP4B, LGI4, LMOD1, MAP1LC3A, NFASC +11 more	View in SCUBA

About the gene

Synonyms	4.1-G, 4.1G
Chromosome	6: 130839347-131063322
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Molecular function	Actin-binding
Biological process	Cell cycle, Cell division, Mitosis, Transport

Function

Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.