PEAR1 — Platelet endothelial aggregation receptor 1
PEAR1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PEAR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory EC Activation Inflammation | ANGPT2, B3GNT5, BAIAP2, EPHA2, GMFB, HIC1, HMOX1, JUP +6 more | View in SCUBA |
About the gene
| Synonyms | FLJ00193, JEDI, MEGF12 |
|---|---|
| Chromosome | 1: 156893698-156916429 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
Function
Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling. May be involved in the early stages of hematopoiesis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.