ANGPT2 — Angiopoietin 2
ANGPT2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANGPT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory EC Activation Inflammation | B3GNT5, BAIAP2, EPHA2, GMFB, HIC1, HMOX1, JUP, LPIN2 +6 more | View in SCUBA |
| Pericytes | BM Collagen Production ECM production | COL18A1, COL4A1, COL4A2, COL5A3, ITGA1, MEST, PXDN, SPARC | View in SCUBA |
About the gene
| Synonyms | Ang2 |
|---|---|
| Chromosome | 8: 6499632-6563409 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted secreted proteins, RAS pathway related proteins |
| Molecular function | Developmental protein |
| Biological process | Angiogenesis, Differentiation |
Function
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.