Inflammatory EC Activation
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes NRIP1 (nuclear receptor coregulator modulating NF-κB inflammatory signaling), HIC1 (transcriptional repressor), ANGPT2 (angiopoietin-2, canonical marker of EC inflammatory activation and vascular destabilization), HMOX1 (heme oxygenase-1, induced by oxidative/inflammatory stress), EPHA2 (upregulated in angiogenesis/inflammation), PDE4B (inflammatory cAMP signaling), and PEAR1 (EC activation receptor) define an inflammatory EC activation program. The module is significantly upregulated in both UC and CD inflammation and downregulated in remission, strongly supporting an inflammation-driven EC activation state. YWHAG (14-3-3γ) and RTN4 support stress/activation signaling. Neighbor M115 is the quiescent counterpart, downregulated in UC inflammation.
Genes
ANGPT2, B3GNT5, BAIAP2, EPHA2, GMFB, HIC1, HMOX1, JUP, LPIN2, MORF4L2, NRIP1, PDE4B, PEAR1, RTN4, YWHAG
Most correlated modules
- Endothelial Cell Migration · correlation 0.74
- Inflammatory Angiogenesis · correlation 0.70
- EC Cytoskeletal Scaffold · correlation 0.67
- Endothelial Chemokine Response · correlation 0.64
- Venous EC Identity · correlation 0.64
- Inflammatory Angiogenesis · correlation 0.59
- CXCL12 Angiogenic Chemotaxis · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.