PNCK — Pregnancy up-regulated nonubiquitous CaM kinase
PNCK belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PNCK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ICC neuromuscular junction Gut motility | ATP1A2, ATRNL1, CASQ2, COL19A1, CTNNA3, FAM83D, KCNIP4, LRRC7 +6 more | View in SCUBA |
| Smooth muscle cells | Microfibrillar ECM Program ECM remodeling | ALDH1A1, CDC42EP3, FGL2, FOXP2, MAB21L2, MFAP2, NREP, OLFML3 +2 more | View in SCUBA |
About the gene
| Synonyms | CaMK1b, MGC45419 |
|---|---|
| Chromosome | X: 153669733-153689010 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase |
Function
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.