FAM83D — Family with sequence similarity 83 member D
FAM83D belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FAM83D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | G2/M Cell Cycle Cell cycle | CCNF, CDC25C, CDCA3, CDCA8, DEPDC1B, FBXO43, HJURP, PRC1 +1 more | View in SCUBA |
| Fibroblasts | ICC neuromuscular junction Gut motility | ATP1A2, ATRNL1, CASQ2, COL19A1, CTNNA3, KCNIP4, LRRC7, MAPK4 +6 more | View in SCUBA |
| Goblet cells | Mitotic Spindle Assembly Cell cycle | ARHGAP11A, AURKA, CDKN3, CENPA, CKAP5, CKS2, KIF14, KNL1 +5 more | View in SCUBA |
| Smooth muscle cells | SMC Ion Signaling Contractility | ANTXR2, ATP1B1, CDKN1C, CENPW, FXYD6, GAS1, KCNMA1, LRIG1 +12 more | View in SCUBA |
About the gene
| Synonyms | C20orf129, CHICA, dJ616B8.3 |
|---|---|
| Chromosome | 20: 38926312-38953106 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC. May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade. May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.