NREP — Neuronal regeneration related protein
NREP belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NREP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | NF-κB Oxidative Stress Stress | ACP1, ALDH7A1, ARHGDIB, CCDC85C, CDC25B, CDKN3, CMSS1, COPRS +13 more | View in SCUBA |
| Goblet cells | Progenitor Identity Program Epithelial development | APEX1, FAM89B, MAP4K4, MEX3A, NOTCH1, RNF186, SOX4, TEAD2 +3 more | View in SCUBA |
| Pericytes | Fibrotic ECM Remodeling ECM remodeling | BGN, CYGB, LAMC3, LGALS3BP, LPL, MMP11, PCDH18, PLOD2 +2 more | View in SCUBA |
| Smooth muscle cells | Microfibrillar ECM Program ECM remodeling | ALDH1A1, CDC42EP3, FGL2, FOXP2, MAB21L2, MFAP2, OLFML3, PNCK +2 more | View in SCUBA |
About the gene
| Synonyms | C5orf13, D4S114, P311, PRO1873, PTZ17, SEZ17 |
|---|---|
| Chromosome | 5: 111662621-111997464 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
May have roles in neural function. Ectopic expression augments motility of gliomas. Also promotes axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.