POMT1 — Protein O-mannosyltransferase 1
POMT1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
POMT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell Coinhibition Immune regulation | BTLA, CASD1, CFAP36, DUSP14, FCHSD2, HIVEP2, IFNGR2, KLF7 +7 more | View in SCUBA |
| Innate lymphoid cells | Actin Cytoskeletal Regulation Cytoskeleton & motility | AQP3, CCDC57, CLPTM1, COTL1, DCAF11, GSN, GYG1, MZT2B +7 more | View in SCUBA |
About the gene
| Synonyms | LGMD2K |
|---|---|
| Chromosome | 9: 131502789-131523806 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha- DAG1 and few other proteins but not of cadherins and protocaherins.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.