POU2F2 — POU class 2 homeobox 2
POU2F2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
POU2F2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell activation B cell maturation | ADAM19, ARHGAP30, CD164, CD19, CD47, CLN8, CPEB4, ELK3 +15 more | View in SCUBA |
| CD4⁺ T cells | Regulatory T cell Immune regulation | ATP1B1, EBI3, FOXP3, GADD45A, GCNT1, GTF2H5, IL1R1, IL1R2 +6 more | View in SCUBA |
| Monocytes | CCR2+ Monocyte Identity Innate immunity | CCR2, GAPT, LYST, MAP3K1, MNDA, RGS18, SLC24A4, TMEM154 +4 more | View in SCUBA |
About the gene
| Synonyms | OCT2, OTF2 |
|---|---|
| Chromosome | 19: 42086110-42196585 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Activates the U2 small nuclear RNA (snRNA) promoter
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.