PPP2R2D — Protein phosphatase 2 regulatory subunit Bdelta
PPP2R2D belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPP2R2D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Polycomb Transcriptional Control DNA/chromatin regulation | AMFR, ATMIN, BRD7, CBX4, CCNY, CD81, CDK2AP1, CSNK1E +17 more | |
| Macrophages | Ubiquitin-Proteasome Regulation Housekeeping | ABCA1, AVL9, EHMT1, GIGYF2, HUWE1, LCORL, PAXBP1, PPP2R5C +4 more | View in SCUBA |
About the gene
| Synonyms | B55D, B55delta, MDS026 |
|---|---|
| Chromosome | 10: 131901008-131959834 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.