EHMT1 — Euchromatic histone lysine methyltransferase 1
EHMT1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EHMT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell signaling regulators B cell maturation | ACAP2, BCL2L11, CDK13, FNBP1, ITSN2, JAK1, KMT2A, ST6GAL1 +3 more | View in SCUBA |
| Macrophages | Ubiquitin-Proteasome Regulation Housekeeping | ABCA1, AVL9, GIGYF2, HUWE1, LCORL, PAXBP1, PPP2R2D, PPP2R5C +4 more | View in SCUBA |
About the gene
| Synonyms | bA188C12.1, EHMT1-IT1, Eu-HMTase1, FLJ12879, FLJ40292, GLP, KIAA1876, KMT1D |
|---|---|
| Chromosome | 9: 137618992-137870016 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Methyltransferase, Transferase |
Function
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.