Ubiquitin-Proteasome Regulation
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include PPP2R5C and PPP2R2D (PP2A phosphatase regulatory subunits), USP47 (deubiquitinase), SMC5 (SMC5/6 complex for DNA repair and cohesion), EHMT1 (G9a-like H3K9 methyltransferase), LCORL (transcriptional repressor), HUWE1 (HECT E3 ubiquitin ligase), ZFX (zinc finger TF), RAF1 (MAPK pathway kinase), GIGYF2 (translational repressor via GYF domain), ABCA1 (ATP-binding cassette cholesterol efflux transporter — a hallmark macrophage lipid homeostasis gene). The module is heterogeneous, combining ubiquitin-proteasome system components, phosphatase signaling, chromatin silencing, and lipid metabolism. ABCA1 is the most biologically distinctive gene in the macrophage context, involved in reverse cholesterol transport. However, given the weak coherence and mixed composition, the module likely reflects a broad post-translational regulatory state. Neighbor context (M38 epigenetic, M35 vesicular) supports a general regulatory program.
Genes
ABCA1, AVL9, EHMT1, GIGYF2, HUWE1, LCORL, PAXBP1, PPP2R2D, PPP2R5C, RAF1, SMC5, USP47, ZFX
Most correlated modules
- Epigenetic Remodeling · correlation 0.99
- Endosomal Vesicle Trafficking · correlation 0.97
- Transcriptional Repression · correlation 0.97
- Transcriptional Regulation · correlation 0.96
- Rho GTPase Signaling · correlation 0.96
- Post-transcriptional Regulation · correlation 0.95
- Chromatin Regulatory Genes · correlation 0.95
- Chromatin Epigenetic Regulation · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.