PTPRK — Protein tyrosine phosphatase receptor type K
PTPRK belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTPRK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Long-gene nuclear transcripts Technical artifact | ARL15, BLNK, CERS6, EXT1, FHIT, FUT8, KANK1, LDLRAD4 +6 more | View in SCUBA |
| Smooth muscle cells | Cytoskeletal Scaffolding Cytoskeletal | AKAP6, C3orf70, CNST, CTTNBP2, DACT3, IQGAP1, KIF13A, KLHL23 +8 more | View in SCUBA |
About the gene
| Synonyms | R-PTP-kappa |
|---|---|
| Chromosome | 6: 127968785-128520616 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Protein phosphatase, Receptor |
Function
Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.