MLXIP — MLX interacting protein
MLXIP belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MLXIP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Autophagy Stress Response Stress | AKIRIN1, BRD9, CDKN2AIP, DHX36, DNAJB2, FOXO3, ODF2L, PPP2R2A +11 more | |
| Goblet cells | Colonocyte Metabolic Defense Mitochondrial & OxPhos | ACAA2, CAT, CRYBG1, GLIPR2, PKDCC, SAMD5, SEMA6A, ZFHX3 | View in SCUBA |
| Macrophages | Post-transcriptional Regulation Housekeeping | AKAP10, ATF7IP, ATRN, ATXN2, BAZ2B, BLTP1, BRWD1, CELF2 +34 more | View in SCUBA |
| Smooth muscle cells | Basement Membrane Matrix ECM remodeling | ADH5, C4orf48, EFEMP2, FBXL7, MXRA8, PRNP, RTN4, VWA1 | View in SCUBA |
About the gene
| Synonyms | bHLHe36, KIAA0867, MIR, MONDOA |
|---|---|
| Chromosome | 12: 122078756-122147344 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.