KIF13A — Kinesin family member 13A
KIF13A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KIF13A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Focal adhesion actin Migration & adhesion | BAZ2B, CARMIL1, COP1, FRYL, LPP, MYO6, PALLD, PTK2 +4 more | View in SCUBA |
| Lymphatic endothelial | Rho/Ras GTPase Regulation Cytoskeletal | ASAP1, CADPS2, CDK17, ERC1, ETV6, LDLRAD4, LMBR1, PLEKHG1 +4 more | View in SCUBA |
| Macrophages | Monocyte Lipid Metabolism Lipid metabolism | ATP13A3, CEP170, CHIC2, COQ10B, CSGALNACT2, ENOSF1, HIPK2, HMGXB3 +14 more | View in SCUBA |
| Neutrophils | Ubiquitin-Proteasome Turnover Housekeeping | BLTP3B, CACUL1, CLIP1, FBXL20, FBXO33, FGD3, IL18RAP, LMTK2 +10 more | |
| Smooth muscle cells | Cytoskeletal Scaffolding Cytoskeletal | AKAP6, C3orf70, CNST, CTTNBP2, DACT3, IQGAP1, KLHL23, NTF3 +8 more | View in SCUBA |
About the gene
| Synonyms | bA500C11.2, RBKIN |
|---|---|
| Chromosome | 6: 17759183-17987635 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Motor protein |
| Biological process | Cell cycle, Cell division, Protein transport, Transport |
Function
Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.