HECTD1 — HECT domain E3 ubiquitin protein ligase 1
HECTD1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HECTD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | DNA damage response DNA/chromatin regulation | ATP2B1, CENPC, DEAF1, FBXO34, HAX1, KMT5C, MRPL50, NDUFA5 +7 more | View in SCUBA |
| Gamma-delta T cells | Wnt-STAT3 Signaling TCR Signaling | BTBD1, COPA, CTNNB1, DHX9, EZR, NUP153, PAFAH1B1, SPRTN +5 more | |
| Innate lymphoid cells | NK ILC Tissue Homing Homing & TEM | ADGRE5, AKAP13, AREG, ARL4C, ATP1B3, B3GNT7, BTG1, CCDC107 +25 more | View in SCUBA |
| Macrophages | Transcriptional Repression Housekeeping | AKAP8, ANKRD11, ARIH2, BACH1, CCNT2, CDK13, CEP95, CSNK1D +23 more | View in SCUBA |
| Monocytes | Glucocorticoid Transcription Inflammatory | JDP2, KLF13, KLF9, PER1, PIK3R1, TMEM123, ZBTB16 | View in SCUBA |
About the gene
| Synonyms | KIAA1131 |
|---|---|
| Chromosome | 14: 31100117-31207804 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.