Actin Cytoskeletal Regulation
Gene co-expression module in Colonocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 18 genes have a known function matching the annotation |
Why this annotation
Top hub genes ROCK1 (Rho-associated kinase) and FNBP1L (formin-binding protein) are canonical regulators of actin cytoskeletal dynamics. PTPRK regulates cell-cell contact via cytoskeletal signaling. WNK1 links ion transport to cytoskeletal organization. PRKAA1 (AMPKα1) modulates cytoskeletal remodeling under energy stress. PBRM1 and CTR9 introduce chromatin/transcription noise, consistent with moderate coherence. The module is best characterized by its actin/cytoskeletal regulatory core.
Genes
Most correlated modules
- RNA-binding & Splicing · correlation 0.91
- Unfolded Protein Response · correlation 0.88
- Focal Adhesion Migration · correlation 0.87
- ER-Golgi Trafficking · correlation 0.87
- Chromatin Regulatory Response · correlation 0.86
- ER-Golgi Trafficking · correlation 0.82
- Chromatin-Coupled Splicing · correlation 0.81
- Inflammasome Activation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.