PTPRR — Protein tyrosine phosphatase receptor type R
PTPRR belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTPRR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | TNF receptor signaling Inflammation | ABHD3, RETREG1, RFK, SECTM1, SLCO2A1, TNFRSF1A | View in SCUBA |
About the gene
| Synonyms | EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ |
|---|---|
| Chromosome | 12: 70638073-70920738 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Protein phosphatase, Receptor |
Function
Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.