Colonocyte Water Transport
Gene co-expression module in Colonocytes
| Category | Absorption |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 40 genes have a known function matching the annotation |
Why this annotation
AQP8 (71.3x sen_colono) is the dominant colonocyte water channel and a hallmark of mature surface colonocytes. AQP7 (13x) is a related aquaglyceroporin. ABCB1 (MDR1/P-glycoprotein, 15.5x) and ABCG2 (20.4x) are major efflux transporters expressed in colonocytes. SLC15A1 (PepT1, 7x) is a peptide/nutrient transporter. TRPM6 mediates Mg2+ absorption. FXYD1 modulates Na/K-ATPase. PRSS23, PRAP1, NAALADL1, SECTM1, LGI4, PTPRR, TIMP2, and LRRN2 are additional sen_colono-enriched genes. The module represents water channel and efflux transporter expression in mature colonocytes.
Genes
Most correlated modules
- Senescent Colonocyte Identity · correlation 0.91
- Brush Border Cytoskeleton · correlation 0.91
- Senescent Colonocyte Differentiation · correlation 0.82
- Inflammatory Colonocyte State · correlation 0.67
- Colonocyte Solute Transport · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.