ABHD3 — Abhydrolase domain containing 3, phospholipase
ABHD3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABHD3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | TNF receptor signaling Inflammation | PTPRR, RETREG1, RFK, SECTM1, SLCO2A1, TNFRSF1A | View in SCUBA |
| Gamma-delta T cells | ER/Osmotic Stress Stress | DNAJA4, FKBP4, HIBCH, HSD17B7, HSPA4, HSPB1, MBNL2, MRPL18 +7 more | |
| Macrophages | MITF Lysosomal Program Lysosomal & pahgocytosis | ANKRD44, ARSB, C2CD5, CERS6, CHST11, CNST, DCTN4, FBXL20 +25 more | View in SCUBA |
About the gene
| Synonyms | LABH3 |
|---|---|
| Chromosome | 18: 21650901-21704780 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Serine esterase |
| Biological process | Lipid metabolism, Phospholipid metabolism |
Function
Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.