RETREG1 — Reticulophagy regulator 1
RETREG1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RETREG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T cell T cell development | ABRAXAS1, ATP10A, BACH2, CASP10, FBLN5, GKAP1, HSBP1L1, MCUB +9 more | View in SCUBA |
| Enterocytes | TNF receptor signaling Inflammation | ABHD3, PTPRR, RFK, SECTM1, SLCO2A1, TNFRSF1A | View in SCUBA |
| Gamma-delta T cells | TCR Signal Regulation TCR Signaling | ADORA2A, ANO9, CAMK4, CASK, CCR5, CD84, CDC14A, CXCR6 +22 more | |
| Hematopoietic progenitor cells | Pro-B Progenitor Lymphcyte development | ARPP21, CD79A, CD79B, CYGB, DNTT, EBF1, FRMD4A, IL2RA +4 more | |
| Innate lymphoid cells | NK JAK3 Signaling activation | ANKRD44, APLP2, ATP8B4, CALCOCO2, ERLEC1, FLOT1, FUT8, FYCO1 +10 more | View in SCUBA |
About the gene
| Synonyms | FAM134B, FLJ20152, JK1 |
|---|---|
| Chromosome | 5: 16473038-16617101 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Autophagy |
Function
Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Active under basal conditions. Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons. (Microbial infection) During SARS-CoV-2 infection, RETREG1- mediated reticulophagy is promoted by SARS-CoV-2 ORF3A protein. This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.