TNF receptor signaling
Gene co-expression module in Enterocytes
| Category | Inflammation |
|---|---|
| Genes | 7 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 7 genes have a known function matching the annotation |
Why this annotation
TNFRSF1A (TNF receptor), SECTM1 (IFN/TNF-inducible ligand), PTPRR, SLCO2A1 (prostaglandin transporter, induced in inflamed epithelium) and RETREG1 point to an inflammatory, cytokine-responsive epithelial state. This is consistent with colonocyte TNF signaling.
Genes
ABHD3, PTPRR, RETREG1, RFK, SECTM1, SLCO2A1, TNFRSF1A
Most correlated modules
- JUN stress response · correlation 0.91
- Stress-responsive transcription · correlation 0.90
- Junctional Hippo/TGF-beta signaling · correlation 0.88
- Surface colonocyte lipid-droplet · correlation 0.88
- Inflammatory hypoxic response · correlation 0.88
- Brush border lipid handling · correlation 0.83
- Epithelial junction polarity · correlation 0.83
- Long-gene nuclear transcripts · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.