ACHE — Acetylcholinesterase (Cartwright blood group)
ACHE belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACHE's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | NF-κB Inflammatory Activation Inflammation | ANKLE2, CD200, CXCL1, CXCL8, HMGA1, ICOSLG, NFKB2, NOD2 +9 more | View in SCUBA |
| Mucosal-associated invariant T cell | BMP/TGF-β Inhibitory Immune regulation | BUD31, FAM43A, ID1, LMNA, N4BP3, PRR7, RGS16, SMAD7 +2 more |
About the gene
| Synonyms | YT |
|---|---|
| Chromosome | 7: 100889994-100896974 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Blood group antigen proteins, Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Blood group antigen, Hydrolase, Serine esterase |
| Biological process | Neurotransmitter degradation |
Function
Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.