PTPRZ1 — Protein tyrosine phosphatase receptor type Z1
PTPRZ1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTPRZ1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Glial Adhesion Identity migration & adhesion | ADAM23, CADM4, CALU, DAG1, HMCN1, HMGN1, ITGA2, SDC3 +2 more | View in SCUBA |
About the gene
| Synonyms | phosphacan, PTP18, PTPRZ, PTPZ, RPTPB |
|---|---|
| Chromosome | 7: 121873089-122062036 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.