Glial Adhesion Identity
Gene co-expression module in Glial cells
| Category | migration & adhesion |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
PTPRZ1 is a canonical marker of enteric and central glia/oligodendrocyte precursors. CADM4 (SynCAM4) mediates glial-axon adhesion and is expressed in myelinating glia. SFRP1 is a secreted Wnt antagonist expressed by enteric glia in homeostasis. DAG1 (dystroglycan) anchors glia to the basement membrane. SDC3 is a heparan sulfate proteoglycan mediating growth factor signaling in glia. ADAM23 is a neural disintegrin involved in synapse organization. SYT11 participates in vesicle trafficking in neural/glial cells. HMCN1 is a basement membrane ECM component. Restored in remission — consistent with a homeostatic glial adhesion/identity program suppressed during inflammation.
Genes
ADAM23, CADM4, CALU, DAG1, HMCN1, HMGN1, ITGA2, PTPRZ1, SDC3, SFRP1, SYT11
Most correlated modules
- Collagen ECM Deposition · correlation 0.85
- ECM Homeostatic Regulation · correlation 0.83
- Glial Neural Scaffolding · correlation 0.81
- TGF-beta Response · correlation 0.81
- Peripheral Glial Myelination · correlation 0.79
- Glial Homeostatic Identity · correlation 0.78
- Glial Vesicle Trafficking · correlation 0.78
- Glial RNA Homeostasis · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.