ITGA2 — Integrin subunit alpha 2
ITGA2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ITGA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | DUOX2 oxidative defense Antibacterial | CD55, CEACAM5, DUOX2, DUOXA2, ENSG00000267881, HK2, TPM4 | View in SCUBA |
| Glial cells | Glial Adhesion Identity migration & adhesion | ADAM23, CADM4, CALU, DAG1, HMCN1, HMGN1, PTPRZ1, SDC3 +2 more | View in SCUBA |
About the gene
| Synonyms | CD49B |
|---|---|
| Chromosome | 5: 52989340-53094779 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Human disease related genes, Plasma proteins, Predicted membrane proteins |
| Molecular function | Host cell receptor for virus entry, Integrin, Receptor |
| Biological process | Cell adhesion, Host-virus interaction |
Function
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.