SDC3 — Syndecan 3
SDC3 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SDC3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | TGF-beta ECM Remodeling ECM remodeling | ADAM10, APLP2, CCNDBP1, CYB5R3, DHRS3, EFEMP2, GNAS, HIPK2 +10 more | View in SCUBA |
| Glial cells | Glial Adhesion Identity migration & adhesion | ADAM23, CADM4, CALU, DAG1, HMCN1, HMGN1, ITGA2, PTPRZ1 +2 more | View in SCUBA |
| Macrophages | Endosomal Membrane Trafficking Vesicular traficking | A2M, AP1B1, ARHGAP4, ARHGEF6, ATG4C, B3GNT7, CRTAP, ETV5 +20 more | View in SCUBA |
| Monocytes | Complement C1q Macrophage Innate immunity | ACP2, C1QA, C1QB, C1QC, CLIC2, DNPH1, GFRA2, ITGA9 +4 more | View in SCUBA |
| Smooth muscle cells | SMC Contractile Signaling Contractility | ACAA2, BOC, CELF2, PLEKHO1, PRUNE2, RGS2, SCARA3 | View in SCUBA |
About the gene
| Synonyms | N-syndecan, SYND3 |
|---|---|
| Chromosome | 1: 30869466-30908758 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Human disease related genes, Predicted membrane proteins |
Function
Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.