CALU — Calumenin
CALU belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CALU's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | ER Calcium Stress Stress | ACOT7, ATP2A2, ELOVL5, GTF2A2, LYAR, PSMD7, RCC2, UFD1 +1 more | View in SCUBA |
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | ADAM9, CLMP, CNN3, GLIPR1, ITGAV, MCRIP1, NAP1L1, PRNP +5 more | View in SCUBA |
| Glial cells | Glial Adhesion Identity migration & adhesion | ADAM23, CADM4, DAG1, HMCN1, HMGN1, ITGA2, PTPRZ1, SDC3 +2 more | View in SCUBA |
| Macrophages | ER-Lysosome Trafficking Vesicular traficking | BPNT2, CLPTM1L, CTSB, DHRS7, EMC10, GBA1, GNS, GPNMB +21 more | View in SCUBA |
| Pericytes | ER Protein Folding Stress | AP2S1, DYNLT1, IKBIP, KDELR2, MYDGF, OSTC, P4HB, PPIB +1 more | View in SCUBA |
| Smooth muscle cells | Collagen Biosynthesis ECM remodeling | COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL6A1, COL6A2, EMILIN1 +4 more | View in SCUBA |
About the gene
| Chromosome | 7: 128739292-128773400 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma- carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.