RO60 — Ro60, Y RNA binding protein
RO60 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RO60's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | CASP8AP2, CNPPD1, CUL4A, CYBC1, EPRS1, FAM8A1, GTF2H3, IL17RA +15 more | |
| Macrophages | mRNA Splicing Processing Housekeeping | AP3D1, BAZ1B, CCDC47, CHTOP, CTCF, EIF1AX, EIF3A, HDLBP +29 more | View in SCUBA |
About the gene
| Synonyms | SSA2, TROVE2 |
|---|---|
| Chromosome | 1: 193059454-193091777 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Ribonucleoprotein, RNA-binding |
| Biological process | Cilium biogenesis/degradation |
Function
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammatory cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes. May play roles in cilia formation and/or maintenance (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.