AP3D1 — Adaptor related protein complex 3 subunit delta 1
AP3D1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AP3D1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Inflammasome Activation Inflammation | ANKRD28, ARHGEF7, CCNH, CD55, CDC42SE1, CHD7, CHKA, CRYBG1 +19 more | View in SCUBA |
| Macrophages | mRNA Splicing Processing Housekeeping | BAZ1B, CCDC47, CHTOP, CTCF, EIF1AX, EIF3A, HDLBP, HNRNPD +29 more | View in SCUBA |
About the gene
| Synonyms | ADTD |
|---|---|
| Chromosome | 19: 2100988-2164468 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Protein transport, Transport |
Function
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T- cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.