EIF1AX — Eukaryotic translation initiation factor 1A X-linked
EIF1AX belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EIF1AX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Anabolic Activation Response Housekeeping | ABHD5, ATF4, ATP6V0C, ATP6V1G1, BCL7B, BUD31, CALM2, CHRAC1 +26 more | |
| Goblet cells | Heat Shock Response Stress | DNAJA1, EIF5, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8, HSPB1 +5 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Housekeeping Mitochondrial & OxPhos | COX7A2, COX7B, EEF1B2, FTH1, HNRNPC, ID2, NAP1L1, POMP +8 more | View in SCUBA |
| Macrophages | mRNA Splicing Processing Housekeeping | AP3D1, BAZ1B, CCDC47, CHTOP, CTCF, EIF3A, HDLBP, HNRNPD +29 more | View in SCUBA |
| Mucosal-associated invariant T cell | Metabolic Homeostasis Housekeeping | ADIPOR1, BIRC3, COQ10B, CREBRF, GNAI3, H2AC20, KLF11, KLHL18 +10 more | |
| Natural Killer cells | NK Cell Activation activation | AKAP9, AKIRIN1, ALG13, DDX24, ETF1, EZR, GNL3, PPP1CB +2 more | View in SCUBA |
| Neutrophils | Translation Initiation Housekeeping | EIF3A, HNRNPA1, NAP1L1, NCL, PPIA, PTMA, RPN2, SET +1 more |
About the gene
| Synonyms | eIF-1A, eIF-4C, EIF1A, EIF4C |
|---|---|
| Chromosome | X: 20124525-20141838 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Initiation factor, RNA-binding, tRNA-binding |
| Biological process | Host-virus interaction, Protein biosynthesis |
Function
Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.