mRNA Splicing Processing
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 38 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 38 genes have a known function matching the annotation |
Why this annotation
The top hub genes are strongly enriched for RNA processing and splicing: KHDRBS1 (Sam68, splicing regulator), EIF3A (translation initiation complex), HNRNPD (AU-rich element RNA binding/mRNA decay), NONO (nuclear RNA processing, paraspeckles), RNPS1 (splicing activator), U2AF2 (U2 snRNP auxiliary factor, splicing), PRPF40A (pre-mRNA processing factor 40), PPIG (spliceosome-associated cyclophilin), ZC3H13 (m6A RNA methylation), EIF1AX (translation initiation), ILF3 (dsRNA-binding, mRNA stability), KPNB1 (importin-beta, nuclear import of splicing factors). RBBP4 and BAZ1B add chromatin remodeling context. The module is enriched in prolif_mac, consistent with elevated RNA processing in proliferating cells. This is a pre-mRNA splicing and RNA processing module.
Genes
AP3D1, BAZ1B, CCDC47, CHTOP, CTCF, EIF1AX, EIF3A, HDLBP, HNRNPD, HNRNPDL, ILF3, IMMT, KHDRBS1, KIF5B, KPNB1, KTN1, LBR, LUC7L2, MTDH, MTPN, NONO, PDE12, PPIG, PRPF40A, RBBP4, RECQL, RNPS1, RO60, SMARCA4, SMARCA5, TIAL1, TPR, TRIP11, U2AF2, U2SURP, YTHDF2, YY1, ZC3H13
Most correlated modules
- Ubiquitin-ERAD Proteostasis · correlation 0.97
- General Cellular Maintenance · correlation 0.96
- RNA Processing Regulation · correlation 0.96
- RNA Splicing Regulation · correlation 0.96
- ER Membrane Homeostasis · correlation 0.96
- Nuclear Pore Transport · correlation 0.95
- RNA Splicing Processing · correlation 0.95
- RNA Processing & Repair · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.