CYBC1 — Cytochrome b-245 chaperone 1
CYBC1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CYBC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | mRNA splicing RNA processing | ANKRD11, ARGLU1, LUC7L3, PLCG2, PNN, SON, SRRM2, TCIRG1 +1 more | View in SCUBA |
| CD4⁺ T cells | Actomyosin signaling migration & adhesion | ACIN1, EIF4G3, GALNT1, HNRNPA3, NCKAP1L, PPP1R12A, PRKCH, PTPRA +8 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | CASP8AP2, CNPPD1, CUL4A, EPRS1, FAM8A1, GTF2H3, IL17RA, KCTD7 +15 more | |
| Macrophages | Lysosomal Hydrolase Program Lysosomal & pahgocytosis | AMDHD2, ARL6IP5, ARPIN, ARSA, CD81, CLDN7, CLEC2B, COMT +35 more | View in SCUBA |
| Mucosal-associated invariant T cell | Immunoproteasome Activity Inflammation | ABRACL, ARPC5, BANF1, CARD16, CISD3, GIMAP2, IMP3, PLAAT4 +4 more |
About the gene
| Synonyms | C17orf62, Eros, FLJ90469, MGC4368 |
|---|---|
| Chromosome | 17: 82440912-82450829 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Chaperone |
| Biological process | Immunity, Innate immunity |
Function
Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer. Controls the phagocyte respiratory burst and is essential for innate immunity (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.