Chromatin Epigenetic Regulation
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 24 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 24 genes have a known function matching the annotation |
Why this annotation
RSBN1L is a histone H4K20 demethylase involved in epigenetic regulation. MPHOSPH8 binds HP1 and is part of the HUSH chromatin silencing complex. CASP8AP2 (FLASH) participates in histone mRNA processing and apoptotic signaling. CUL4A is a ubiquitin ligase involved in chromatin-coupled DNA damage repair. N4BP2L2 is a nuclear transcriptional regulator. MRPS5/31 are mitochondrial small subunit ribosomal proteins, a secondary signal. The module is moderate coherence and likely a mixed program dominated by chromatin/epigenetic regulation with mitochondrial ribosomal components as minor contributors.
Genes
CASP8AP2, CNPPD1, CUL4A, CYBC1, EPRS1, FAM8A1, GTF2H3, IL17RA, KCTD7, KIAA0040, LSM10, MCRIP1, MPHOSPH8, MRPS31, MRPS5, N4BP2L2, OMA1, PIGF, RO60, RRP36, RSBN1L, SEPTIN7, TMEM120A, USO1
Most correlated modules
- SR Kinase & RNA · correlation 0.86
- ER-Lysosomal Trafficking · correlation 0.86
- T cell Survival · correlation 0.85
- DNA Damage Repair · correlation 0.79
- Interferon Antiviral Response · correlation 0.78
- Mitochondrial Dynamics · correlation 0.77
- Antiviral ISG Response · correlation 0.76
- TGF-beta Signaling · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.