SDCCAG8 — SHH signaling and ciliogenesis regulator SDCCAG8
SDCCAG8 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SDCCAG8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Rho GTPase Signaling Cytoskeletal | APOBR, ARHGEF3, ATP6V1H, BRCC3, CD46, CNDP2, CYB5R4, DCTN5 +14 more | |
| Macrophages | Chromatin Regulatory Genes Housekeeping | ACAP2, ARID4A, ATRX, BPTF, BRD10, BRD4, EP300, ERBIN +31 more | View in SCUBA |
About the gene
| Synonyms | BBS16, CCCAP, NPHP10, NY-CO-8, SLSN7 |
|---|---|
| Chromosome | 1: 243256034-243500091 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Cilium biogenesis/degradation |
Function
Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.