ERBIN — Erbb2 interacting protein
ERBIN belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ERBIN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T-cell costimulation TCR/AP1/NFKb pathway | ASH1L, BOD1L1, CCM2, CCR4, CD28, CREBRF, DDX27, ICOS +10 more | View in SCUBA |
| Enterocytes | Brush-border enterocyte Absorption | CD2AP, CEACAM20, GK, HHLA2, MAN1A1, MAPK6, NCKAP5, SLC36A1 | View in SCUBA |
| Gamma-delta T cells | DNA Damage Response DNA/chromatin regulation | AP1B1, CCAR1, CHD8, DOCK2, EP400, GOLM2, IPO8, LRBA +17 more | |
| Glial cells | ENS Developmental TFs Development | FRMD3, HAND2, LRRC4C, MAP4K4, PYGL, SEC11C, SLC25A36, TBX3 +2 more | View in SCUBA |
| Lymphatic endothelial | ZEB1-driven EMT endothelial development | ASH1L, CUX1, ITSN2, KIF1B, MKLN1, NFAT5, NIPBL, PAFAH1B1 +7 more | View in SCUBA |
| Macrophages | Chromatin Regulatory Genes Housekeeping | ACAP2, ARID4A, ATRX, BPTF, BRD10, BRD4, EP300, ETNK1 +31 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Migration migration & adhesion | AP3B1, ATP9B, BIRC6, BTBD9, CEP350, DOCK11, DOCK2, FRYL +8 more |
About the gene
| Synonyms | ERBB2IP, LAP2 |
|---|---|
| Chromosome | 5: 65883128-66082546 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.