Chromatin Regulatory Genes
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 40 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 40 genes have a known function matching the annotation |
Why this annotation
Hub genes include BPTF, ATRX, KDM5A, WAC, PHF3, NIPBL — all chromatin remodeling or transcriptional regulators. TRIP12 and MARCHF7 are E3 ubiquitin ligases involved in chromatin-coupled proteostasis. ZEB2 is a transcription factor. MACF1 and HOOK3 are cytoskeletal. The module is weakly coherent with uniform expression, suggesting co-variation of large regulatory genes due to transcriptional output or cell complexity rather than a specific program. Neighbor modules M112 and M5 similarly contain large housekeeping/RNA-processing genes, supporting a housekeeping interpretation.
Genes
ACAP2, ARID4A, ATRX, BPTF, BRD10, BRD4, EP300, ERBIN, ETNK1, GAPVD1, GOLGB1, HOOK3, HYCC2, INO80D, KDM5A, KPNA4, LONP2, MACF1, MARCHF7, MED13, NIPBL, NUFIP2, PHF3, PHIP, POLR2A, PRR14L, PUM1, RAB3GAP2, RBM26, RICTOR, RSF1, SDCCAG8, TAOK1, TRIP12, WAC, YY1AP1, ZEB2, ZNF292, ZNF451, ZNF638
Most correlated modules
- RNA Processing Housekeeping · correlation 0.97
- Post-transcriptional Regulation · correlation 0.97
- Sphingolipid Membrane Homeostasis · correlation 0.96
- ER-Golgi Trafficking · correlation 0.95
- mRNA Splicing Processing · correlation 0.95
- Epigenetic Remodeling · correlation 0.95
- Transcriptional Repression · correlation 0.95
- Ubiquitin-Proteasome Regulation · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.