ACAP2 — ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
ACAP2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACAP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell signaling regulators B cell maturation | BCL2L11, CDK13, EHMT1, FNBP1, ITSN2, JAK1, KMT2A, ST6GAL1 +3 more | View in SCUBA |
| CD4⁺ T cells | DNA repair/replication DNA/chromatin regulation | BROX, CCDC88C, CKAP2, EPM2AIP1, FOXO3, HAUS3, HELB, KMT2C +4 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Signaling Immune regulation | ABCF1, ABHD12, ADIPOR2, CBX6, ENPP4, FBXO9, GSAP, INPP4A +18 more | |
| Macrophages | Chromatin Regulatory Genes Housekeeping | ARID4A, ATRX, BPTF, BRD10, BRD4, EP300, ERBIN, ETNK1 +31 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Epigenetic Regulation DNA/chromatin regulation | APBB1IP, ARHGAP25, ATM, CD247, CHD9, CLCN3, DDX17, FLI1 +14 more | |
| Neutrophils | Actin Cytoskeletal Remodeling Cytoskeletal | ARHGAP15, COP1, CUX1, DOCK8, DPYD, KDM2A, MED13L, MKLN1 +9 more |
About the gene
| Synonyms | CENTB2, CNT-B2, KIAA0041 |
|---|---|
| Chromosome | 3: 195274745-195443044 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.