SEL1L — SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
SEL1L belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEL1L's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Ubiquitin-ERAD Proteostasis Housekeeping | GSPT1, HSPA9, ITCH, MAPK1IP1L, PANK3, PJA2, TOR1AIP2, USP39 +1 more | View in SCUBA |
About the gene
| Synonyms | Hrd3, IBD2, SEL1L1 |
|---|---|
| Chromosome | 14: 81471547-81533853 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Host-virus interaction, Notch signaling pathway |
Function
Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.