GSPT1 — G1 to S phase transition 1
GSPT1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GSPT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR signaling TCR/AP1/NFKb pathway | AP3M2, ATP1B3, CREM, CRYBG1, DCTN6, EZR, FAM177A1, FTH1 +19 more | View in SCUBA |
| Endothelial | Actin Cytoskeletal Remodeling Cytoskeletal | ACTR2, ANKRD11, ARPC4, CAP1, EIF4G1, FYTTD1, G3BP1, IPO7 +8 more | View in SCUBA |
| Gamma-delta T cells | TCR Threshold Regulation TCR Signaling | AGO2, ATP8A1, AUTS2, CMIP, CNOT6L, CSNK1D, FOXO1, MAP3K8 +8 more | |
| Hematopoietic progenitor cells | DNA Damage Repair Housekeeping | HNRNPR, LARS1, MSH6, NCL, PARP1, PRKDC, SUPT16H | |
| Macrophages | Ubiquitin-ERAD Proteostasis Housekeeping | HSPA9, ITCH, MAPK1IP1L, PANK3, PJA2, SEL1L, TOR1AIP2, USP39 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | AP-1/MEF2 Activation T cell maturation | ADNP2, BHLHE40, CDK16, DBF4, ETF1, FOSL2, GADD45A, GPR35 +8 more |
About the gene
| Synonyms | eRF3a, ETF3A, GST1 |
|---|---|
| Chromosome | 16: 11868128-11916082 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Nonsense-mediated mRNA decay, Protein biosynthesis |
Function
GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA. GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.