Ubiquitin-ERAD Proteostasis
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
The two highest-PageRank genes are E3 ubiquitin ligases: PJA2 (PRAJA2, RING-type E3 ligase targeting PKA regulatory subunits) and ITCH (NEDD4-family E3 ligase). SEL1L is a core component of the ERAD (ER-associated degradation) complex. USP39 is a deubiquitinase (also involved in splicing). HSPA9 is a mitochondrial HSP70 chaperone involved in protein quality control. MAPK1IP1L interacts with MAPK signaling. GSPT1 is a translation termination factor. Together, the dominant theme is ubiquitin-mediated protein quality control and ERAD, consistent with a protein homeostasis/proteostasis program in macrophages. Small module with all-weak membership limits certainty.
Genes
GSPT1, HSPA9, ITCH, MAPK1IP1L, PANK3, PJA2, SEL1L, TOR1AIP2, USP39, WBP11
Most correlated modules
- RNA Processing Regulation · correlation 0.98
- ER Membrane Homeostasis · correlation 0.97
- General Cellular Maintenance · correlation 0.97
- mRNA Splicing Processing · correlation 0.97
- ER-Golgi Trafficking · correlation 0.96
- RNA Splicing Regulation · correlation 0.95
- Autophagy Vesicular Trafficking · correlation 0.95
- Pre-mRNA Splicing · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.