SERPINB2 — Serpin family B member 2
SERPINB2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SERPINB2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | NF-κB Inflammatory Activation Inflammatory | ADM, CCL2, CCL20, CCL7, CLEC4E, CXCL1, CXCL2, CXCL3 +19 more | View in SCUBA |
| Monocytes | IgA-Monocyte Activation Innate immunity | AATK, AREG, ASPH, ATP2A3, CD82, FCAR, NIBAN2, SLC16A6 +3 more | View in SCUBA |
About the gene
| Synonyms | HsT1201, PAI-2, PAI2, PLANH2 |
|---|---|
| Chromosome | 18: 63871692-63903888 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Protease inhibitor, Serine protease inhibitor |
| Biological process | Plasminogen activation |
Function
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.