ADM — Adrenomedullin
ADM belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Angiogenesis ECM remodeling | APOD, CHST15, CMTM3, GPIHBP1, GRAP, HOMER3, LOX, MYH10 +7 more | View in SCUBA |
| Fibroblasts | Unfolded Protein Response Stress | AFF4, DDX3X, DLL1, EIF4A1, ERN1, HNRNPA2B1, HNRNPH1, HNRNPU +5 more | View in SCUBA |
| Macrophages | NF-κB Inflammatory Activation Inflammatory | CCL2, CCL20, CCL7, CLEC4E, CXCL1, CXCL2, CXCL3, CXCL5 +19 more | View in SCUBA |
| Neutrophils | Immediate Early Response Stress | BTG2, DUSP1, EGR1, FOS, IER2, JUNB, ZFP36 |
About the gene
| Synonyms | AM |
|---|---|
| Chromosome | 11: 10305073-10307397 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hormone |
Function
Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. ADM function is mediated by the CALCRL- RAMP2 and CALCRL-RAMP3 receptor complexes with ADM showing the highest potency for the CALCRL-RAMP2 complex.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.