CXCL1 — C-X-C motif chemokine ligand 1
CXCL1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CXCL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Chemokine Response Chemotaxis | BMP2, CCL2, CEBPB, CEBPD, CNKSR3, CXCL2, CXCL3, CXCL8 +14 more | View in SCUBA |
| Fibroblasts | Cytokine Chemokine Secretion Inflammatory | CCL2, CSF3, CXCL3, CXCL8, G0S2, GLIS3, IL6, RIPK2 +1 more | View in SCUBA |
| Lymphatic endothelial | NF-κB Inflammatory Activation Inflammation | ACHE, ANKLE2, CD200, CXCL8, HMGA1, ICOSLG, NFKB2, NOD2 +9 more | View in SCUBA |
| Macrophages | NF-κB Inflammatory Activation Inflammatory | ADM, CCL2, CCL20, CCL7, CLEC4E, CXCL2, CXCL3, CXCL5 +19 more | View in SCUBA |
| Neutrophils | Chemokine Secretion Cytokine & chemokine secretion | CXCL2, CXCL8, DDIT3, GADD45B, GLUL, HCAR2, IER5, MAFF +3 more | |
| Pericytes | NF-kB Chemokine Response Inflammatory | CCL2, CCL8, CXCL2, NCOA7, PRDM1, SOD2, TNFAIP3 | View in SCUBA |
About the gene
| Synonyms | FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1 |
|---|---|
| Chromosome | 4: 73869393-73871308 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Cytokine, Growth factor |
| Biological process | Inflammatory response |
Function
Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO- alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.