CXCL2 — C-X-C motif chemokine ligand 2

CXCL2 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CXCL2's module in each cell type

Cell type	Module	Shares the module with
Endothelial	Endothelial Chemokine Response Chemotaxis	BMP2, CCL2, CEBPB, CEBPD, CNKSR3, CXCL1, CXCL3, CXCL8 +14 more	View in SCUBA
Fibroblasts	Cytokine Inflammatory Response Inflammatory	DNAJB4, GFPT2, HES4, MAP3K8, MMP19, RASL11A, RGCC, RND3 +4 more	View in SCUBA
Glial cells	NF-κB/IFN Inflammatory Inflammation	BIRC3, CTSS, CXCL10, CXCL9, FDCSP, HAPLN3, ICAM1, PTX3 +4 more	View in SCUBA
Innate lymphoid cells	Prostaglandin-AP1 Response Inflammation	ARIH1, ARL5B, CCNT1, CHD1, ETV3, FOSL2, IRF2BP2, JOSD1 +12 more	View in SCUBA
Macrophages	NF-κB Inflammatory Activation Inflammatory	ADM, CCL2, CCL20, CCL7, CLEC4E, CXCL1, CXCL3, CXCL5 +19 more	View in SCUBA
Monocytes	Immediate-Early Inflammatory Inflammatory	CXCL3, CXCL8, DUSP2, EGR1, EGR2, NFKBIA, NFKBIZ, OTUD1 +3 more	View in SCUBA
Neutrophils	Chemokine Secretion Cytokine & chemokine secretion	CXCL1, CXCL8, DDIT3, GADD45B, GLUL, HCAR2, IER5, MAFF +3 more
Pericytes	NF-kB Chemokine Response Inflammatory	CCL2, CCL8, CXCL1, NCOA7, PRDM1, SOD2, TNFAIP3	View in SCUBA
Smooth muscle cells	Stromal Chemokine Secretion Inflammation	C7, CCL19, CCL2, CCL21, CH25H, CXCL12, LINC00924, MAOA +9 more	View in SCUBA

About the gene

Synonyms	CINC-2a, GRO2, GROb, MGSA-b, MIP-2a, SCYB2
Chromosome	4: 74097040-74099196
Predicted location	Secreted
Essential gene	No
Protein class	Cancer-related genes, Plasma proteins, Predicted secreted proteins
Molecular function	Cytokine
Biological process	Chemotaxis, Inflammatory response

Function

Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.