CCL2 — C-C motif chemokine ligand 2
CCL2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Chemokine Response Chemotaxis | BMP2, CEBPB, CEBPD, CNKSR3, CXCL1, CXCL2, CXCL3, CXCL8 +14 more | View in SCUBA |
| Fibroblasts | Cytokine Chemokine Secretion Inflammatory | CSF3, CXCL1, CXCL3, CXCL8, G0S2, GLIS3, IL6, RIPK2 +1 more | View in SCUBA |
| Lymphatic endothelial | Hypoxic Stress Response Stress | CHMP1B, ID2, IER3, IFRD1, RRAD, SOX4, VEGFA | View in SCUBA |
| Macrophages | NF-κB Inflammatory Activation Inflammatory | ADM, CCL20, CCL7, CLEC4E, CXCL1, CXCL2, CXCL3, CXCL5 +19 more | View in SCUBA |
| Monocytes | Monocyte Chemokine Secretion Inflammatory | ACOD1, ADAM19, CCL7, CLEC5A, CXCL11, GBP3, IL27 | View in SCUBA |
| Pericytes | NF-kB Chemokine Response Inflammatory | CCL8, CXCL1, CXCL2, NCOA7, PRDM1, SOD2, TNFAIP3 | View in SCUBA |
| Smooth muscle cells | Stromal Chemokine Secretion Inflammation | C7, CCL19, CCL21, CH25H, CXCL12, CXCL2, LINC00924, MAOA +9 more | View in SCUBA |
About the gene
| Synonyms | GDCF-2, HC11, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF |
|---|---|
| Chromosome | 17: 34255274-34257208 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Human disease related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Chemotaxis, Inflammatory response |
Function
Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.