CXCL3 — C-X-C motif chemokine ligand 3
CXCL3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CXCL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Chemokine Response Chemotaxis | BMP2, CCL2, CEBPB, CEBPD, CNKSR3, CXCL1, CXCL2, CXCL8 +14 more | View in SCUBA |
| Fibroblasts | Cytokine Chemokine Secretion Inflammatory | CCL2, CSF3, CXCL1, CXCL8, G0S2, GLIS3, IL6, RIPK2 +1 more | View in SCUBA |
| Macrophages | NF-κB Inflammatory Activation Inflammatory | ADM, CCL2, CCL20, CCL7, CLEC4E, CXCL1, CXCL2, CXCL5 +19 more | View in SCUBA |
| Monocytes | Immediate-Early Inflammatory Inflammatory | CXCL2, CXCL8, DUSP2, EGR1, EGR2, NFKBIA, NFKBIZ, OTUD1 +3 more | View in SCUBA |
About the gene
| Synonyms | CINC-2b, GRO3, GROg, MIP-2b, SCYB3 |
|---|---|
| Chromosome | 4: 74036589-74038807 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Chemotaxis, Inflammatory response |
Function
Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.