NF-κB Inflammatory Activation
Gene co-expression module in Macrophages
| Category | Inflammatory |
|---|---|
| Genes | 28 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 18 of 28 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by NF-κB-driven chemokines (CXCL1/2/3/5, CCL7, CCL20) and pro-inflammatory cytokines (IL1A, IL1B, INHBA), all hallmarks of acute inflammatory macrophage activation. Supporting genes include IER3 (NF-κB target), TNFAIP6 (TNF-stimulated), ADM (inflammation-induced), MAP2K3 (p38 MAPK), PPP1R15A (stress/ISR), KLF10 (inflammatory TF), and CLEC4E (innate immune receptor). The module is enriched in mono_mac, consistent with classically activated monocyte-derived macrophages. Despite weak per-gene membership scores (likely due to subset-restricted activation), the biological program is coherent and represents NF-κB-driven acute inflammatory activation.
Genes
ADM, CCL2, CCL20, CCL7, CLEC4E, CXCL1, CXCL2, CXCL3, CXCL5, EAF1, IER3, IL1A, IL1B, IL1RN, IL6, INHBA, KLF10, MAP2K3, MSANTD3, NT5E, PPBP, PPP1R15A, RRAS, SAV1, SERPINB2, THAP2, TNF, TNFAIP6
Most correlated modules
- Inflammatory Monocyte Activation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.