CCL7 — C-C motif chemokine ligand 7
CCL7 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCL7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Interferon Response Inflammatory | A4GALT, ABCA1, ABHD17C, BASP1, CLEC2B, IFI16, IFI6, PLSCR1 +5 more | View in SCUBA |
| Macrophages | NF-κB Inflammatory Activation Inflammatory | ADM, CCL2, CCL20, CLEC4E, CXCL1, CXCL2, CXCL3, CXCL5 +19 more | View in SCUBA |
| Monocytes | Monocyte Chemokine Secretion Inflammatory | ACOD1, ADAM19, CCL2, CLEC5A, CXCL11, GBP3, IL27 | View in SCUBA |
About the gene
| Synonyms | FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7 |
|---|---|
| Chromosome | 17: 34270221-34272242 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Cytokine, Heparin-binding |
| Biological process | Chemotaxis, Inflammatory response |
Function
Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.