BLNK — B cell linker

BLNK belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

BLNK's module in each cell type

Cell type	Module	Shares the module with
Enterocytes	Long-gene nuclear transcripts Technical artifact	ARL15, CERS6, EXT1, FHIT, FUT8, KANK1, LDLRAD4, LRBA +6 more	View in SCUBA
Fibroblasts	Adventitial Fibroblast State Developmental	AKAP7, C1QA, CACNA1G, CALCRL, COL21A1, CYP1B1, FAT3, KIRREL2 +9 more	View in SCUBA
Hematopoietic progenitor cells	Dendritic Cell Progenitor Myeloid development	CCDC50, CD180, CLEC4A, HDAC9, HERPUD1, IRF8, LY86, NCF1 +1 more

About the gene

Synonyms	BASH, bca, BLNK-s, Ly57, SLP-65, SLP65
Chromosome	10: 96189171-96271587
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Predicted intracellular proteins
Biological process	B-cell activation

Function

Functions as a central linker protein, downstream of the B- cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR- mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR- induced B-cell apoptosis.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.